Mitochondrial_Pearling

The Biophysical Mechanism of Mitochondrial Pearling

A repository of videos, images, and code related to the manuscript, “The Biophysical Mechanism of Mitochondrial Pearling”

Published in Molecular Biology of the Cell @MBoC

Cover art mito pearling

Sturm G, Hake K, Lefebvre AEYT, Rux CJ, Ivanova D, Millett-Sikking A, Tharp KM, Rao B, Closser M, Waite AJ, Precido-Lopez M, Ritter AT, Dumont S, Lu W, Manley S, Landoni JC, Marshall WF. The biophysical mechanism of mitochondrial pearling. Mol Biol Cell. 2025 Nov 1;36(11):ar142. doi: 10.1091/mbc.E25-06-0302. Epub 2025 Oct 8. PMID: 41060791; PMCID: PMC12586885.

Blender preview of organelle simulation

Our mechanism captures how pearling is regulating by the three physical forces:

  1. Pressure
  2. Elasticity
  3. Tension

Fig8_low_res

Preprint available as a preprint @BioRxiv

An additional manuscript by Lanoni et al., detailing the the functional implications of mitochondrial pearling on nucleoid spacing is available as a preprint @BioRxiv

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